Precision microbiome ingredients for healthy aging
Trilliome is a Swiss biotechnology company developing plant-derived, clinically validated ingredients that precisely modulate keystone gut microbial networks and their metabolites to target hallmarks of aging — enabling next-generation supplements and functional foods for cognition, mood and long-term healthspan.
We partner with supplement and functional food brands to bring serious microbiome science to everyday products.
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The gut–brain–immune axis behind modern ailments
Modern lifestyles disrupt the gut microbiome: chronic stress, processed diets and environmental factors drive a state of imbalance (dysbiosis). This goes far beyond digestion. Dysbiosis is increasingly linked to brain fog, mood disturbances and chronic low-grade inflammation — key features of accelerated biological aging.
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Cognitive decline & brain fog
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A disrupted gut ecosystem can reduce the microbial production of key metabolites that support brain function. This imbalance is associated with difficulties in concentration, memory and sustained mental performance.
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Mood, stress & mental resilience
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Many neurotransmitters and “feel-good” factors involved in mood regulation are influenced by the gut microbiome. When this network is disturbed, it can impact stress responses and emotional resilience.
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Systemic inflammation
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Dysbiosis can impair gut barrier integrity. This “leaky” state allows microbial products to reach the bloodstream, contributing to chronic, low-grade inflammation throughout the body — a key hallmark of aging.
Targeting microbial networks that drive brain and immune health
TRI-01: a precision bioactive that enriches key gut-protective species
TRI-01 is a first-in-class, plant-derived microbiome bioactive discovered through our in-vitro and AI-guided engine. It selectively nourishes gut-resident bacteria associated with anti-inflammatory and brain-protective metabolite production, strengthening the gut–brain axis at the root level.
Designed as a scalable ingredient for supplement and functional food formulations, TRI-01 is backed by human-relevant ex-vivo data and is being advanced into targeted clinical evaluation.
- Boost of gut-resident, brain-linked anti-inflammatory bacteria
- +45-fold
- Short-chain fatty acids associated with cognitive & immune protection
- +150%
- Gut-resident probiotic species supporting barrier integrity (“anti-leaky gut”)
- +250%
- Consistent efficacy and high tolerability across diverse microbiomes, without discomfort (e.g. bloating)
- +/+
Meet the team pioneering precision microbiome ingredients
Our founders combine deep scientific expertise with global biotech and nutrition experience to build microbiome-mediated ingredients that support brain health, immunity and healthy aging.
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Patrick Guye, PhD MBA
Co-Founder & CEO
Patrick is a biotech executive and scientist with leadership roles across pharma and startups, including CSO, COO and Entrepreneur-in-Residence. His work spans inflammatory, metabolic and age-related diseases, backed by training in synthetic biology and infection biology from MIT and the University of Basel. At Trilliome, he leads company strategy and helps shape scientific direction to advance precision microbiome-based health solutions.
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Tim Mak, PhD MBA
Co-Founder & CBO
Tim is a scientist and strategist with experience across microbiome research, pharma and consumer health at Johnson & Johnson and dsm-firmenich. He trained at the Max Planck Institute and the University of Cambridge and brings deep expertise in translating science into global impact. At Trilliome, he leads commercial strategy and co-leads scientific direction to drive innovation in microbiome-powered healthy aging.
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