Why delivery fails

The keystone species behind brain and metabolic health are strict anaerobes: oxygen kills them, so they cannot survive manufacturing, a shelf or a stomach. Bulk fiber feeds the whole community at 5–10 g a day and cannot choose which species grow.

Switch on what's there

TRI-01 is a plant-derived small molecule that switches on four keystone species already living in the gut:

  • Agathobaculum butyriciproducens
  • Coprococcus catus
  • Anaerostipes hadrus
  • Faecalibacillus intestinalis

Nothing alive, no cold chain, and a dose in milligrams.

What the species make

  • Immune. Butyrate trains the gut's immune cells and calms the low-grade inflammation of aging.
  • Metabolic. C. catus and A. hadrus make propionate by their own route, a signal for blood sugar and metabolic health.
  • Brain. C. catus makes DOPAC, a dopamine metabolite; short-chain fatty acids signal to the brain through the vagus nerve.
the four species what they are known to do Agathobaculum butyriciproducens Coprococcus catus Anaerostipes hadrus Faecalibacillus intestinalis immune & inflammatory control Short-chain fatty acids act on immune signaling in the gut wall — where inflammatory tone is set. metabolic signaling C. catus and A. hadrus make propionate, by a route separate from butyrate. neuroactive output C. catus makes DOPAC, a dopamine metabolite. Published animal work on A. butyriciproducens: amyloid-β burden and cognition (Lee 2020), synaptogenesis (Song 2024), dopaminergic neuroprotection (Bok 2022). SCFAs are one route of three. The hard part is reaching these species at all.
Published work on the species What the published literature shows these four species do.

The lead species, A. butyriciproducens, reduced amyloid-β burden and improved cognition (Lee 2020), matured synapses (Song 2024) and protected dopamine neurons (Bok 2022) in published animal models.

TRI-04: the same biology, through fiber

TRI-04 feeds the butyrate and propionate producers directly: a low-MW, water-soluble fiber for the gut barrier and a healthy inflammatory response.

A working chain every stage feeds the next one Dietary fiber complex, slow Primary degraders break it down Lactate & acetate the intermediate Keystone consortium the four species Butyrate, propionate + neuroactive output The host gut wall, and past it What thins it age · antibiotics · diet Dietary fiber unchanged Primary degraders still working Lactate & acetate still made — and left Keystone consortium thinned out Output collapses The host little arrives The chain doesn't fail loudly. The intermediates are still made — there is nobody left to convert them. More input does not fix that. Where we act two ways into the same chain Dietary fiber complex, slow Primary degraders fed and acted on Lactate & acetate the intermediate Keystone consortium induced, converting again Butyrate, propionate + neuroactive output The host supply restored TRI-04 arrives as a dietary fiber — and acts on the degraders that break fiber down TRI-01 induces these species
Schematic — no quantities shown The stages are the site's own biology: Anaerostipes hadrus and Coprococcus catus both live off lactate the stages above them release, which is why propionate is a separate route rather than part of the butyrate story. TRI-04 acts at the front of the chain in two ways at once, TRI-01 on the consortium itself. The host end From the published work on these molecules: short-chain fatty acids act on immune signaling in the gut wall, propionate on blood-sugar signaling, and DOPAC and short-chain fatty acids reach the brain directly and through the vagus nerve.

One engine

Both products come from Teroka, which learns which plant actives, and which combinations, move which species and signals.

Why can't you just put these bacteria in a probiotic?
They're strict anaerobes — they die on contact with oxygen and can't survive manufacturing or shelf life.
What does "activation" mean?
Inducing beneficial species already present in the gut, rather than delivering live cells or bulk substrate.
Is this just about butyrate?
No. Butyrate is one beneficial output; these keystone species also produce neuroactive and immunomodulatory factors, and Agathobaculum butyriciproducens in particular has a published capacity to modulate neuroinflammation that butyrate alone doesn't explain.
Which species does TRI-01 target?
A named four-species consortium: Agathobaculum butyriciproducens, Coprococcus catus, Anaerostipes hadrus, Faecalibacillus intestinalis.
How is this different from a prebiotic fiber like inulin, FOS or GOS?
Those are bulk substrates. Bacteria consume them, so the delivered mass sets the effect and the intake runs to grams. A modulator changes what resident species do without being eaten by them, which is why it works at milligrams. The full comparison — probiotics, prebiotics, postbiotics — is here.
How much goes into a serving?
Milligrams, where conventional prebiotic fibers need 5 to 10 grams. The figure for each active is on its own product page.
Does it need refrigeration?
No. These are plant-derived small molecules with nothing alive in them, so there is no viability to protect and no cold chain.