Insights

Defining the category, in the open.

Opinion and thought leadership from our scientists — on the gut-brain axis, precision modulation of the microbiome, the biology of keystone gut species, and what "evidence" should mean for functional ingredients.

Insight · 4 min read

Mopping off the floor without turning off the faucet

Five pharma leaders on one stage at ARDD 2026, and one image for the whole morning. Medicine is very good at cleaning up after disease. The harder job is stopping it at the source.

Patrick Guye — Co-Founder & CEO
Insight · 7 min read

The brain is not sealed

The immune cells defending your brain were supposed to last a lifetime. New human data shows they start being replaced around fifty, and the replacements are educated somewhere unexpected.

Patrick Guye — Co-Founder & CEO
Brain Health · 4 min read

A remote control for memory, hidden in the gut

A new Nature paper shows an aging gut can drive memory loss on its own — and reverse it. The twist is which molecule does the damage.

Patrick Guye — Co-Founder & CEO
Science · 5 min read

A GLP-1 drug treated depression without touching its receptor

A GLP-1 drug relieved depression in mice with its receptor deleted. The effect ran through a single gut bacterium, not the brain. What the science says about the gut microbiome and mental health, and where it doesn't.

Patrick Guye — Co-Founder & CEO
Insight · 2 min read

Beyond biotics: the case for precision bioactives

Probiotics add live bacteria; fibre feeds them in bulk. Our co-founder Tim Mak told Fi Global about a third path — plant-derived bioactives that reprogramme the gut bacteria a person already carries.

Trilliome Staff
Brain Health · 4 min read

The window for fixing the gut-brain axis closes earlier than we thought

A systematic review of fifteen trials points to a mid-life prevention window for gut-brain interventions — and it appears to close before clinical disease begins.

Patrick Guye — Co-Founder & CEO
Nutrition · 3 min read

Diversity is key to a healthy gut

Nutrition & Longevity: Walking through Hong Kong's markets — greens, reds, purples, and yellows — highlights a vital truth: diversity in diet is essential for a healthy gut and overall well-being.

Patrick Guye — Co-Founder & CEO
Insight · 1 min read

Biotech: Building a Commercial Culture

Embrace commercial innovation early, even if it requires leadership changes — key insights from Ed Salzman's presentation at the Swiss HLG annual meeting.

Patrick Guye — Co-Founder & CEO